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February 1, 2002AJP Gastrointestinal and Liver Physiology

Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle

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Population

Rat stomach circular smooth muscle cells (fundus and antrum)

Design

Preclinical

Authors

SOSusumu OhyaNagoya City UniversityKAKeiichi AsakuraNippon Shinyaku (Japan)KMKatsuhiko MurakiGriffith University

Discussion

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Implication

Rat gastric K+ channel expression informs basic SMC physiology; leaves open translation to human gastric motility or therapeutics.

Structured PICO

P
Population
Rat stomach circular smooth muscle cells (fundus and antrum)
I
Intervention
E-4031 (1 microM) and indapamide
O
Outcome
Expression of ERG, KCNQ, and KCNE subtypes and their contribution to membrane currents (I(Kr) and I(Ks))surrogate

I(Kr)- and I(Ks)-like currents in rat stomach smooth muscle cells are attributable to ERG1/KCNE2 and KCNQ1/KCNE1 expression, respectively, contributing to resting membrane potential.

Cite This Study

Ohya et al. (2002) studied this question.

synapsesocial.com/papers/6a6fbd64febe604dd708971ahttps://doi.org/10.1152/ajpgi.00200.2001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.1990 · 1,472 citations
  2. 2Patch‐clamp studies of slow potential‐sensitive potassium channels in longitudinal smooth muscle cells of rabbit jejunum1983 · 101 citations
  3. 3Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus.1990 · 190 citations
  4. 4Potassium currents in rat prevertebral and paravertebral sympathetic neurones: control of firing properties.1995 · 135 citations
  5. 5N‐linked glycosylation sites determine HERG channel surface membrane expression1999 · 148 citations