Selective elimination of IK,slow1 via a dominant negative Kv1.5 subunit in mouse ventricular myocytes prolongs action potential and QT interval without causing electrical remodeling or spontaneous arrhythmias.
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QT prolongation via selective IK,slow1 loss does not induce arrhythmias in mice; leaves open human translational relevance.
Li et al. (2004) studied this question.
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