Why the study?
Does combined suppression of Ito and IK,slow alter action potential duration and spontaneous arrhythmias in mice?
Does combined suppression of Ito and IK,slow alter action potential duration and spontaneous arrhythmias in mice?
The attenuation of fast Ito in addition to IK,slow in mice causes significant prolongation of APD and Q-T intervals but attenuates spontaneous arrhythmias, suggesting that APD and Q-T prolongation are not inherently proarrhythmic.
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Decouples QT prolongation from arrhythmogenesis in mice; leaves open whether APD extension is proarrhythmic in humans.
Brunner et al. (2001) studied this question.
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