Why the study?
The mechanism to regain the proliferative capacity of human adult cardiomyocytes for heart repair after injury remains a challenge.
Design
Review
Authors
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Promising pathway modulation may enable adult cardiomyocyte proliferation; leaves open clinical translation for post-injury repair.
Understanding the molecular switch mechanisms that regulate cardiomyocyte cell cycle re-entry provides potential therapeutic targets for cardiac regeneration after injury.
Hashmi et al. (2019) studied this question.
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