Key result
Targeted expression of cyclin D2 in postnatal mouse hearts resulted in a greater than 500-fold increase in cell cycle activity, leading to infarct regression and improved cardiac hemodynamics.
Why the study?
Does targeted expression of cyclin D2 induce myocardial repair and improve cardiac hemodynamics following myocardial infarction in postnatal mice?
Population
Postnatal transgenic mice expressing cyclin D2 under the myosin heavy chain promoter and their nontransgenic…
Comparison
Constitutive targeted expression of cyclin D2 in… vs Nontransgenic littermates subjected to the same…
Design
Review
Follow-up
180 days
Authors
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Premature for clinical use post-MI; leaves open whether cyclin D2 can drive human myocardial regeneration.
Does targeted expression of cyclin D2 induce myocardial repair and improve cardiac hemodynamics following myocardial infarction in postnatal mice?
Constitutive expression of cyclin D2 in postnatal mouse hearts induces cardiomyocyte proliferation, leading to infarct regression and functional recovery after myocardial infarction.
Zhu et al. (2009) conducted a review in Myocardial injury. Targeted expression of cyclin D2 vs. Nontransgenic siblings was evaluated. Targeted expression of cyclin D2 in postnatal mouse hearts resulted in a greater than 500-fold increase in cell cycle activity, leading to infarct regression and improved cardiac hemodynamics.
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