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October 24, 2017OncotargetOpen Access

11β-HSD1 inhibition ameliorates diabetes-induced cardiomyocyte hypertrophy and cardiac fibrosis through modulation of EGFR activity

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Why the study?

Does selective 11β-HSD1 inhibition prevent structural and functional features of diabetic cardiomyopathy in murine models of diabetes and cultured cardiomyocytes?

Population

Type 1 and type 2 murine models of diabetes and cultured cardiomyocytes

Design

Preclinical

Authors

CZChunpeng ZouWenzhou Medical UniversityWLWeixin LiIcahn School of Medicine at Mount SinaiYPYong PanShenzhen University

Discussion

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Overview

May support 11β-HSD1 inhibition in diabetic cardiomyopathy; leaves open need for clinical trials.

Structured PICO

Does selective 11β-HSD1 inhibition prevent structural and functional features of diabetic cardiomyopathy in murine models of diabetes and cultured cardiomyocytes?

P
Population
Type 1 and type 2 murine models of diabetes and cultured cardiomyocytes
I
Intervention
Selective 11β-HSD1 inhibitor
O
Outcome
Structural and functional features of diabetic cardiomyopathy including fibrosis and hypertrophysurrogate

Inhibition of 11β-HSD1 ameliorates diabetes-induced cardiomyocyte hypertrophy and cardiac fibrosis through modulation of EGFR activity, suggesting a potential therapeutic strategy for diabetic cardiomyopathy.

Cite This Study

Zou et al. (2017) studied this question.

synapsesocial.com/papers/6a6fbddfa7fbea1e4407d61dhttps://doi.org/10.18632/oncotarget.22015
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