Why the study?
Cardiac fibrosis is a major feature of diabetic cardiomyopathy, and whether miR-155 inhibition ameliorates cardiac fibrosis via the Nrf2/HO-1 signaling pathway was investigated.
Does miR-155 inhibition ameliorate high glucose-induced cardiac fibrosis and apoptosis in H9C2 rat cardiomyocytes?
Population
H9C2 rat cardiomyocytes cultured with high glucose
Comparison
miR-155 inhibitor and miR-155 mimic transfection vs controls
Design
In vitro controlled laboratory study
Authors
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No immediate clinical implications in diabetic cardiomyopathy; leaves open miR-155 inhibition as a therapeutic target.
Does miR-155 inhibition ameliorate high glucose-induced cardiac fibrosis and apoptosis in H9C2 rat cardiomyocytes?
Inhibition of miR-155 ameliorates high glucose-induced cardiac fibrosis and apoptosis in vitro by enhancing the Nrf2/HO-1 signaling pathway, suggesting a potential therapeutic target for diabetic cardiomyopathy.
Li et al. (2020) studied this question.
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