Key result
Early down-regulation of miR-15a/b activates fibrotic signalling in the diabetic heart, and its therapeutic restoration reduces the activation of pro-fibrotic TGFβR1 and CTGF.
Early down-regulation of miR-15a/b activates fibrotic signaling in the diabetic heart, suggesting it as a potential therapeutic target for diabetes-induced fibrotic remodeling.
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Suggests miR-15a/b restoration for diabetic cardiac fibrosis; hypothesis-generating, requiring human validation before clinical consideration.
Rawal et al. (2017) studied Type 2 diabetes. Therapeutic restoration of miR-15a and -15b vs. Non-diabetic controls was evaluated on Fibrotic remodelling and expression of TGFβR1, CTGF, and p53. Early down-regulation of miR-15a/b activates fibrotic signalling in the diabetic heart, and its therapeutic restoration reduces the activation of pro-fibrotic TGFβR1 and CTGF.
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