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January 13, 2022Canadian Journal of Physiology and Pharmacology

Overexpression of miR-30a-5p reduced Smad2 levels, inhibited collagen formation in high glucose-stimulated cardiac fibroblasts and diabetic rats, and decreased fibroblast proliferation.

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Why the study?

Cardiac fibrosis is a major feature of diabetic cardiomyopathy and miRNAs regulate its progression, but the role of miR-30a-5p and its underlying mechanism in diabetic cardiomyopathy required investigation.

Population

Streptozotocin-induced diabetic rats and high glucose-treated rat primary cardiac fibroblasts

Comparison

miR-30a-5p overexpression vs controls

Design

Preclinical animal and in vitro cellular study

Discussion

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Overview

miR-30a-5p overexpression curbs fibroblast proliferation and collagen in diabetic rat models; leaves open therapeutic translation pending human studies.

Structured PICO

P
Population
Rat model of diabetes mellitus established by streptozotocin injection, and rat primary cardiac fibroblasts treated with high glucose
I
Intervention
Overexpression of miR-30a-5p
C
Comparator
Control (no overexpression / high glucose alone)
O
Outcome
Proliferation and collagen formation of cardiac fibroblasts, and Smad2 expressionsurrogate

miR-30a-5p inhibits cardiac fibroblast proliferation and collagen formation in diabetic cardiomyopathy by targeting Smad2, suggesting a potential therapeutic target for cardiac fibrosis.

Cite This Study

A 2022 study studied this question.

synapsesocial.com/papers/6a90de3517bbbfe73e74485bhttps://doi.org/10.1139/cjpp-2021-0280
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MicroRNA-195-5p Downregulation Inhibits Endothelial Mesenchymal Transition and Myocardial Fibrosis in Diabetic Cardiomyopathy by Targeting Smad7 and Inhibiting Transforming Growth Factor Beta 1-Smads-Snail Pathway2021 · 35 citations
  2. 2miR‐30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy2015 · 71 citations
  3. 3Inhibition of microRNA‐150‐5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose‐treated cardiac fibroblasts2019 · 59 citations
  4. 4MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-κB signalling pathway2021 · 36 citations
  5. 5Cardiac miR‐133a overexpression prevents early cardiac fibrosis in diabetes2014 · 201 citations