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April 8, 2021The Journal of Biochemistry

MiR-20a-5p overexpression improved cardiac dysfunction, prevented cardiomyocyte apoptosis, alleviated cardiac hypertrophy and fibrosis, and inhibited the JNK/NF-κB pathway via modulating ROCK2.

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Why the study?

MiR-20a-5p is declined in hearts of diabetic mice, but its effect on diabetic cardiomyopathy remains unknown.

Does miR-20a-5p overexpression improve diabetic cardiomyopathy in preclinical models?

Population

Streptozotocin-induced DCM rat model and high glucose-stimulated H9C2 model of DCM

Comparison

Adenovirus expressing miR-20a-5p treatment

Design

In vivo and in vitro animal and cell study

Authors

XLXiaoyu LiuBGBingyan GuoWZWei Zhang

Discussion

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Member takes

Overview

Supports miR-20a-5p as a target in diabetic cardiomyopathy models; leaves open translation to human therapy.

Structured PICO

Does miR-20a-5p overexpression improve diabetic cardiomyopathy in preclinical models?

P
Population
Streptozotocin-induced diabetic cardiomyopathy (DCM) rat model and high glucose-stimulated H9C2 cell model of DCM
I
Intervention
Adenovirus expressing miR-20a-5p
O
Outcome
Cardiac dysfunction, apoptosis, hypertrophy, fibrosis, and JNK/NF-κB signalling pathwaysurrogate

MiR-20a-5p overexpression ameliorates diabetic cardiomyopathy in preclinical models by inhibiting inflammation, apoptosis, hypertrophy, and fibrosis via the ROCK2/JNK/NF-κB pathway.

Cite This Study

Liu et al. (2021) studied this question.

synapsesocial.com/papers/6a82a1942403b1e95c46f8a2https://doi.org/10.1093/jb/mvab047
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Also Consider

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  1. 1miR-200a-3p overexpression alleviates diabetic cardiomyopathy injury in mice by regulating autophagy through the FOXO3/Mst1/Sirt3/AMPK axis2023 · 22 citations
  2. 2Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy2022 · 32 citations
  3. 3miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy2022 · 26 citations
  4. 4MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin2018 · 98 citations
  5. 5miR‐30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy2015 · 71 citations