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March 17, 2015Cardiovascular TherapeuticsOpen Access

miR-30c overexpression decreased Cdc42 and Pak1 genes and attenuated HG-induced cardiomyocyte hypertrophy, whereas miR-30c inhibition increased Cdc42 and Pak1 gene expression and myocyte hypertrophy.

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Population

Wistar rats with diabetic cardiomyopathy induced by low-dose streptozotocin-high-fat diet, patients with…

Comparison

miR-30c overexpression and inhibition (in vitro) vs Control rats and normal glucose-treated…

Design

Preclinical

Follow-up

12 weeks (for rat model)

Authors

SRSatish K. RautAKAkhilesh KumarGSGurinder Bir Singh

Discussion

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Overview

Identifies miR-30c-Cdc42/Pak1 as potential target in diabetic cardiomyopathy models; hypothesis-generating and requires in vivo validation.

Structured PICO

P
Population
Wistar rats with diabetic cardiomyopathy (DCM) induced by low-dose streptozotocin-high-fat diet, patients with DCM, and high-glucose (HG)-treated H9c2 cardiomyocytes
I
Intervention
miR-30c overexpression and inhibition (in vitro)
C
Comparator
Control rats and normal glucose-treated cardiomyocytes
O
Outcome
Cardiac expression of Cdc42, Pak1, miR-30c, and hypertrophy markers (ANP and β-MHC)surrogate

Downregulation of miR-30c mediates prohypertrophic effects of hyperglycemia in diabetic cardiomyopathy by upregulating Cdc42 and Pak1 genes, identifying a potential therapeutic target.

Cite This Study

Raut et al. (2015) studied this question.

synapsesocial.com/papers/6a833fb6efd7bfb18d4871dehttps://doi.org/10.1111/1755-5922.12113
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy2022 · 26 citations
  2. 2MiR-29a regulates cardiomyocyte apoptosis by targeting Bak1 in diabetic cardiomyopathy2022 · 11 citations
  3. 3MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-κB signalling pathway2021 · 36 citations
  4. 4MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα2019 · 115 citations
  5. 5MicroRNA: unveiling novel mechanistic and theranostic pathways in diabetic cardiomyopathy2025 · 7 citations