September 30, 2015Expert Opinion on Therapeutic Targets
Targeting danger-associated molecular patterns after myocardial infarction
Why the study?
Does targeting danger-associated molecular patterns (DAMPs) and pattern recognition receptors reduce infarct size and preserve cardiac function after myocardial infarction?
Population
Patients with myocardial infarction and experimental animal models of MI
Design
Review
Authors
Discussion
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Member takes
Implication
May support post-MI anti-inflammatory targeting to limit remodeling; leaves open clinical efficacy in HF prevention.
Structured PICO
Does targeting danger-associated molecular patterns (DAMPs) and pattern recognition receptors reduce infarct size and preserve cardiac function after myocardial infarction?
P
Population
Patients with myocardial infarction and experimental animal models of MI
I
Intervention
Targeting danger-associated molecular patterns (DAMPs) and pattern recognition receptors (PRRs), specifically TLR2, TLR4, and NLRP3-inflammasome signaling
O
Outcome
Infarct size and cardiac function post-MI
Targeting the early inflammatory response via DAMPs and PRRs (such as TLR2, TLR4, and NLRP3) represents a promising therapeutic strategy to attenuate left ventricular remodeling and prevent heart failure after myocardial infarction.
Cite This Study
Hout et al. (2015) studied this question.