Why the study?
Does angiotensin II infusion reveal increased systemic and renal vascular sensitivity in normotensive men with a positive family history of hypertension compared to those without?
Does angiotensin II infusion reveal increased systemic and renal vascular sensitivity in normotensive men with a positive family history of hypertension compared to those without?
Normotensive men with a positive family history of hypertension exhibit increased systemic and renal vascular sensitivity to angiotensin II, suggesting an early pathophysiological mechanism for hypertension development.
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Should not yet inform screening or therapy; leaves open whether angiotensin II sensitivity predicts incident hypertension.
Widgren et al. (1992) studied this question.
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