What question did this study set out to answer?

This study investigates the pressor responsiveness to angiotensin II in patients with hypertensive disease, particularly in those with renovascular hypertension.

April 1, 1964Journal of Clinical InvestigationOpen Access

The Effect of Angiotensin II on the Blood Pressure in Humans with Hypertensive Disease*

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Why the study?

Does pressor responsiveness to exogenous angiotensin help diagnose renovascular hypertension in patients with hypertensive disease?

Population

Patients with various hypertensive diseases and experimental models

Design

Cross-sectional

Authors

NKNorman M. KaplanBrookings Institution JSJack G. SilahUniversity of Toronto

Discussion

Member takes

Implication

May support angiotensin pressor testing for renovascular hypertension diagnosis; leaves open prospective validation before clinical adoption.

Key Points

This study investigates the pressor responsiveness to angiotensin II in patients with hypertensive disease, particularly in those with renovascular hypertension.
Examined pressor responses to exogenous angiotensin and l-norepinephrine in various experimental conditions.
Studied patients with different hypertensive diseases to assess their responsiveness to angiotensin.
Identified relationships between endogenous angiotensin levels and pressor response variability.
Patients with secondary hyperaldosteronism showed reduced pressor responsiveness to angiotensin.
The analysis revealed diminished responsiveness in patients with renovascular hypertension compared to controls.
Pressor responsiveness to angiotensin may serve as a diagnostic tool for renovascular hypertension.

Structured PICO

Does pressor responsiveness to exogenous angiotensin help diagnose renovascular hypertension in patients with hypertensive disease?

Population

Patients with various hypertensive diseases (including secondary hyperaldosteronism and renovascular hypertension) and experimental models (dogs)

Intervention

Exogenous angiotensin and l-norepinephrine

Outcome

Pressor responsiveness (blood pressure response)surrogate

Pressor responsiveness to exogenous angiotensin may serve as a diagnostic test for renovascular hypertension.

Cite This Study

Kaplan et al. (1964) studied this question.

synapsesocial.com/papers/6a6fc203febe604dd7089bf6 https://doi.org/10.1172/jci104951

Topics

Hypertension management

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Implication

May support angiotensin pressor testing for renovascular hypertension diagnosis; leaves open prospective validation before clinical adoption.

The Effect of Angiotensin II on the Blood Pressure in Humans with Hypertensive Disease*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The Effect of Angiotensin II on the Blood Pressure in Humans with Hypertensive Disease*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider