Why the study?
Does 250 microg ACTH stimulation compared to 1 microg ACTH stimulation alter measured cortisol response in patients across different stress levels?
Population
74 subjects divided into three groups with increasing stress levels: ambulatory controls, hospitalized…
Comparison
250 microg ACTH stimulation test vs 1 microg ACTH stimulation test
Design
RCT, randomized to either a 1- or 250-microg dose
Authors
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250 μg ACTH elicits higher peak cortisol than 1 μg in stressed patients; challenges low-dose equivalence for adrenal testing and extends HPA axis dose-response data.
Does 250 microg ACTH stimulation compared to 1 microg ACTH stimulation alter measured cortisol response in patients across different stress levels?
In moderate and major stress situations, cortisol concentrations are higher after stimulation with 250 microg compared with 1 microg ACTH, providing insight into HPA axis adaptations to stress.
Widmer et al. (2005) studied this question.
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