Why the study?
Does a submaximal dose of ACTH reveal a diurnal variation in cortisol response when basal cortisol is suppressed?
Population
Humans (implied)
Comparison
ACTH stimulation at varying doses and at… vs Different doses of ACTH and different times of…
Design
Other
Follow-up
30 minutes
Authors
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1 μg ACTH suffices for maximal stimulation; leaves open whether submaximal dosing detects diurnal sensitivity outside cortisol suppression.
Does a submaximal dose of ACTH reveal a diurnal variation in cortisol response when basal cortisol is suppressed?
1.0 microgram ACTH is the lowest dose for maximal cortisol stimulation, and using submaximal doses reveals no diurnal variation in adrenal sensitivity to ACTH when basal cortisol is suppressed.
Dickstein et al. (1997) studied this question.
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