Why the study?
Although lipoprotein(a) levels are associated with carotid artery stenosis, their relation to carotid atherosclerotic plaque composition and morphology is less known.
Are higher lipoprotein(a) levels and lipoprotein(a)-related SNPs associated with vulnerable carotid plaque characteristics in patients with symptomatic carotid artery stenosis?
Population
182 patients of the Plaque At RISK study
Comparison
Lipoprotein(a) levels, apo(a) KIV-2 repeats, and LPA SNPs
Design
Observational cohort study
Authors
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May refine carotid plaque risk assessment in stroke patients; leaves open sex-specific Lp(a) effects on vulnerability.
Are higher lipoprotein(a) levels and lipoprotein(a)-related SNPs associated with vulnerable carotid plaque characteristics in patients with symptomatic carotid artery stenosis?
In patients with symptomatic carotid artery stenosis, increased lipoprotein(a) levels are associated with vulnerable plaque characteristics such as lipid-rich necrotic core and thin-or-ruptured fibrous cap.
Dam-Nolen et al. (2021) studied this question.
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