Population
Single head of muscle myosin (S1) and actin filaments observed in vitro
Comparison
Application of various force levels up to 4 pN vs Low load (<1 pN)
Design
Preclinical
Authors
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Supports stochastic actomyosin motor behavior under load; leaves open translation to cardiac muscle physiology.
The fundamental mechanical properties of muscle contraction can be explained by the intrinsic stochastic nature of individual actomyosin motors.
Kitamura et al. (2005) studied this question.
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