December 29, 2004Philosophical Transactions of the Royal Society B Biological SciencesOpen Access

Coupling between phosphate release and force generation in muscle actomyosin

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Population

Muscle actomyosin / muscle fibres

Design

Review

Authors

KHKenneth C. HolmesMassachusetts Eye and Ear Infirmary DTDavid R. TrenthamKing's College London RSRobert SimmonsGoogle (United States)

Discussion

Member takes

Implication

Refines actomyosin force-generation model; extends structural-kinetic synthesis but leaves open cardiac translation pending functional studies.

Structured PICO

Population

Muscle actomyosin / muscle fibres

Outcome

Mechanism of coupling between phosphate release and force generation

This review synthesizes structural and kinetic data to explain the molecular mechanism of force generation and phosphate release in muscle actomyosin.

Cite This Study

Holmes et al. (2004) studied this question.

synapsesocial.com/papers/6a6fc6116ceb2bbd16dfb9ff https://doi.org/10.1098/rstb.2004.1561

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Implication

Refines actomyosin force-generation model; extends structural-kinetic synthesis but leaves open cardiac translation pending functional studies.