Key result
FRET and transient kinetic experiments identified a pre-force-generation actomyosin ADP/Pi state with a closed actin binding cleft and closed nucleotide binding pocket.
Authors
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Refines cross-bridge cycle models; extends prior kinetics but leaves clinical relevance in heart disease open.
Sun et al. (2008) studied this question. In vitro actomyosin cross-bridge cycle analysis was evaluated on Conformational changes in the actin binding cleft. FRET and transient kinetic experiments identified a pre-force-generation actomyosin ADP/Pi state with a closed actin binding cleft and closed nucleotide binding pocket.
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