Key result
An 8-Å cryoEM reconstruction of myosin V in the force-generating ADP state reveals a closed actin-binding cleft and a novel β-sheet conformation underlying the nucleotide pocket.
Population
Myosin V motors bound to actin
Comparison
8-Å cryoEM reconstruction and molecular dynamics… vs Subsequent state on actin (Rigor)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open functional validation of myosin states in muscle.
The study reveals the detailed structural rearrangements underlying myosin force generation and strain-dependent ADP release essential for processive myosins.
Wulf et al. (2016) studied this question. An 8-Å cryoEM reconstruction of myosin V in the force-generating ADP state reveals a closed actin-binding cleft and a novel β-sheet conformation underlying the nucleotide pocket.
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