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July 20, 2018The Open Ophthalmology JournalOpen Access

A Review of Corneal Collagen Cross-linking – Current Trends in Practice Applications

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Authors

LLLi LimMinistry of HealthELElizabeth Wen Ling LimSingapore National Eye Center

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Overview

Literature review demonstrates corneal collagen cross-linking halts ectasia progression in keratoconus and infectious keratitis, indicating expanding therapeutic applications beyond standard...

Key Points

  • To evaluate current clinical literature regarding established and emerging applications of corneal collagen cross-linking.
  • Conducted a comprehensive review of publications including systematic reviews, randomized controlled trials, cohort studies, case-control studies, and case series.
  • Synthesized and tabulated comparative outcomes across standard epithelium-off protocols, epithelium-on techniques, accelerated protocols, and combination therapies.
  • The standard epithelium-off Dresden protocol consistently arrests the progression of keratoconus and post-LASIK ectasia while yielding progressive improvements in visual, keratometric, and topographic parameters with rare severe complications.
  • Epithelium-on cross-linking displays lower efficacy compared to the Dresden protocol, while accelerated protocols demonstrate inconsistent efficacy ranging from comparable outcomes to reduced effectiveness.
  • Cross-linking effectively treats infective keratitis as an adjuvant therapy, demonstrating greater therapeutic success in superficial over deep infections and bacterial over fungal etiologies.

Cite This Study

Lim et al. (2018) studied this question.

synapsesocial.com/papers/6a6fc7ff78a11c550e098cfahttps://doi.org/10.2174/1874364101812010181
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Science and Clinical Evolution of Corneal Cross-Linking: Mechanism of Action, Ultra-Structural Changes, Clinical Indications, and Emerging Treatment Strategies2026
  2. 2Clinical Aspects of Corneal Collagen Crosslinking Various Modifications2024
  3. 3Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions: theoretical basis2024 · 6 citations
  4. 4Corneal Cross-Linking in Keratoconus: A Scoping Review of Clinical Evidence and Public Health Implications2025
  5. 5A safe and effective method for thin cornea cross-linking2024