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September 27, 2025Open Access

Corneal Cross-Linking in Keratoconus: A Scoping Review of Clinical Evidence and Public Health Implications

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Authors

RORodrigo Ojeda-SalamancaBVBryan VillagraNVNicolás Figueroa VargasNational University of Quilmes

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Overview

Scoping review reveals corneal cross-linking effectively stabilizes keratoconus and highlights public health implications.

Key Points

  • CXL halts keratoconus progression in 90–95% of cases, showing significant efficacy for patients.
  • Among 43 studies, retrospective designs were most common, focusing on adult populations and treatment outcomes.
  • The accelerated CXL protocol demonstrated comparable efficacy with advantages for pediatric patients and safer applications.
  • Evidence supports CXL's cost-effectiveness, making it a public health priority but highlights gaps in protocol standardization.

Cite This Study

Ojeda-Salamanca et al. (2025) studied this question.

synapsesocial.com/papers/68d7cc6aeebfec0fc5238b09https://doi.org/10.21203/rs.3.rs-7714413/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Corneal Cross-linking in Pediatric Populations: Systematic Review and Future Perspectives.2025
  2. 2Corneal Cross-Linking for Pediatric Keratoconus2024 · 1 citations
  3. 3Clinical Outcomes and Safety of Customized Corneal Cross-linking for Keratoconus: A Systematic Review and Meta-analysis2026 · 2 citations
  4. 4The Science and Clinical Evolution of Corneal Cross-Linking: Mechanism of Action, Ultra-Structural Changes, Clinical Indications, and Emerging Treatment Strategies2026
  5. 5Two-to-three-year effectiveness and safety of nurse-led accelerated corneal crosslinking for progressive keratoconus: The Birmingham and Midland Eye Centre Study2026