Why the study?
Does moderate renal impairment alter the pharmacokinetics of orally administered enalapril and benazepril in dogs?
Population
10 dogs with surgically induced moderate experimental renal impairment
Comparison
Single oral administration of enalapril or… vs The same dogs before experimental renal impairment
Design
Preclinical, randomly assigned to 2 groups of 5 animals in a 2-period…
Authors
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May warrant enalapril dose caution in renally impaired dogs; leaves open differential ACEI selection for prospective veterinary trials.
Does moderate renal impairment alter the pharmacokinetics of orally administered enalapril and benazepril in dogs?
Exposure to enalaprilat, but not benazeprilat, is significantly increased in dogs with subclinical renal impairment.
Lefèbvre et al. (1999) studied this question.
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