Population
6 excised, cross-circulated rat heart preparations from retired breeder male crj: Wistar rats
Comparison
Stepwise increased Ca2+ intracoronary infusion vs Control volume run without inotropic interventions
Design
Preclinical
Authors
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May enable oxygen cost quantification in rodent models with curved ESPVR; leaves open translation to human LV energetics.
A novel equivalent end-systolic pressure-volume ratio at a mid-range LV volume allows for the calculation of the oxygen cost of contractility in rat hearts with curved end-systolic pressure-volume relations.
Tsuji et al. (1999) studied this question.
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