Why the study?
Does myosin isozyme shift or left ventricular contractility determine the curvilinearity of the left ventricular ESPVR in rat hearts?
Population
In situ rat hearts (normal and hypothyroid models)
Comparison
Hypothyroidism, dobutamine administration, and… vs Normal rats (myosin isozyme V1)
Design
Preclinical
Authors
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Contractility, not myosin isozyme, dictates ESPVR curvilinearity in rats; leaves open relevance to human ventricular assessment.
Does myosin isozyme shift or left ventricular contractility determine the curvilinearity of the left ventricular ESPVR in rat hearts?
The curvilinearity of the left ventricular end-systolic pressure-volume relation in rats is determined by left ventricular contractility rather than the specific myosin isozyme.
Lee et al. (1998) studied this question.
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