What question did this study set out to answer?

To determine the incidence of HIV-1-related clinical signs, mortality rates, and prognostic markers of disease progression and death in infants exposed to HIV-1 from birth.

October 1, 1996The Pediatric Infectious Disease Journal

Prospective study of human immunodeficiency virus 1-related disease among 512 infants born to infected women in New York City

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Authors

MBMahrukh BamjiNew York City Health and Hospitals Corporation DTDonald M. TheaBoston University JWJeremy WeedonSUNY Downstate Health Sciences University

Discussion

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Implication

Prospective cohort study observes rapid disease progression and CD4 thresholds predicting AIDS in HIV-1-infected infants, highlighting the need for early clinical monitoring.

Key Points

To determine the incidence of HIV-1-related clinical signs, mortality rates, and prognostic markers of disease progression and death in infants exposed to HIV-1 from birth.
Prospective multicenter cohort of 512 infants (116 HIV-1-infected and 396 uninfected) monitored from birth for a median of 26 months across 7 hospitals between 1986 and 1995.
Clinical evaluations and laboratory assessments were conducted roughly bimonthly during the first two years of life, utilizing Kaplan-Meier and Cox proportional hazards regression analyses.
By 1 year of age, 83% of infected infants developed at least two nonspecific HIV symptoms, AIDS, or died; estimated infant mortality was 160 per 1,000 live births, and 64% remained alive and AIDS-free at 1 year.
Forty-three percent (50/116) developed AIDS, with Pneumocystis carinii pneumonia occurring in 38% (19/50) of these cases as the leading cause of death; median survival post-AIDS was 21 months.
A CD4 count ≤ 1500 cells/µL measured at 3 to 6 months predicted subsequent AIDS progression (68% [13/19] vs. 30% [18/61] in those with > 1500 cells/µL, P = 0.0001), whereas birth CD4 levels showed no predictive value.

Cite This Study

Bamji et al. (1996) studied this question.

synapsesocial.com/papers/6a6fcc716ceb2bbd16dfbb7f https://doi.org/10.1097/00006454-199610000-00012

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Implication

Prospective cohort study observes rapid disease progression and CD4 thresholds predicting AIDS in HIV-1-infected infants, highlighting the need for early clinical monitoring.

Prospective study of human immunodeficiency virus 1-related disease among 512 infants born to infected women in New York City

Discussion

Member takes

Implication

Key Points

Cite This Study

Prospective study of human immunodeficiency virus 1-related disease among 512 infants born to infected women in New York City

Discussion

Member takes

Implication

Key Points

Cite This Study

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