What question did this study set out to answer?

To characterize the clinical, immunologic, and psychosocial outcomes of children surviving with perinatally acquired HIV infection beyond 9 years of age.

May 1, 1995PEDIATRICS

Older Children and Adolescents Living With Perinatally Acquired Human Immunodeficiency Virus Infection

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To characterize the clinical, immunologic, and psychosocial outcomes of children surviving with perinatally acquired HIV infection beyond 9 years of age.
Descriptive cohort study of N=42 surviving perinatally HIV-infected children older than 9 years followed at an inner-city hospital AIDS program as of June 1993.
Retrospectively analyzed medical records for clinical status, CD4+ lymphocyte counts, and psychosocial measures over a mean follow-up of 48 months post-diagnosis.
At diagnosis (mean age 88 months), 59.5% were asymptomatic; after a mean follow-up of 48 months, 23.8% remained asymptomatic, 19.1% had non-AIDS-defining symptoms, and 57.1% progressed to AIDS.
CD4+ lymphocyte counts declined by an average of 71.4 cells/microL annually between ages 7 and 16 years, leaving 50% with counts <200 cells/microL, 28.6% between 200–500 cells/microL, and 21.4% >500 cells/microL.
Maternal death orphaned 76% of patients, with 60% cared for by extended family; 57.1% had received disease disclosure, and 76% attended standard schooling.

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Implication

Cohort study observes significant immune decline and symptom progression in older children with perinatal HIV, highlighting ongoing medical and psychosocial challenges.

Cite This Study

Grubman et al. (1995) studied this question.

synapsesocial.com/papers/6aa38020c715cee61e21cd38 https://doi.org/10.1542/peds.95.5.657

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Implication

Cohort study observes significant immune decline and symptom progression in older children with perinatal HIV, highlighting ongoing medical and psychosocial challenges.

Older Children and Adolescents Living With Perinatally Acquired Human Immunodeficiency Virus Infection

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Discussion

Implication

Cite This Study

Older Children and Adolescents Living With Perinatally Acquired Human Immunodeficiency Virus Infection

Key Points

Discussion

Implication

Cite This Study

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