November 13, 2013American Journal of Epidemiology
Associations Between Short-term Changes in Air Pollution and Correlates of Arterial Stiffness: The Veterans Affairs Normative Aging Study, 2007–2011
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Why the study?
Does short-term exposure to ambient air pollution increase correlates of arterial stiffness (augmentation index and augmentation pressure) in elderly men?
Population
370 elderly men from the Veterans Affairs Normative Aging Study in the Boston, Massachusetts metropolitan…
Design
Cohort
Follow-up
Up to 2 visits between 2007 and 2011
Authors
Discussion
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Implication
No practice change from this observational link; extends evidence for vascular effects of particles in elderly men.
Structured PICO
Does short-term exposure to ambient air pollution increase correlates of arterial stiffness (augmentation index and augmentation pressure) in elderly men?
P
Population
370 elderly men from the Veterans Affairs Normative Aging Study in the Boston, Massachusetts metropolitan area, mean age 78.0 years, 97.3% white. Key comorbidities include hypertension (79.2%), coronary heart disease (38.4%), and diabetes mellitus (21.6%).
I
Intervention
Short-term exposure to ambient air pollution (PM2.5, black carbon, particle number counts, sulfate, nitrogen dioxide, and ozone) assessed as moving averages over 4 hours, 24 hours, 3, 7, and 14 days.
O
Outcome
Central augmentation index (AIx, as %) and augmentation pressure (AP, in mmHg) measured by radial artery applanation tonometry for pulse wave analysis.surrogate
Short-term exposure to ambient air pollution, particularly particle number counts and PM2.5, is associated with increased correlates of arterial stiffness in elderly men, supporting a vascular mechanism for air pollution-related cardiovascular events.
Limitations
- Loss to follow-up prior to the collection of PWA measurements may have led to a healthier selection of participants resulting in a downward bias
- AIx is a measure of wave reflection and considered a negative effect of arterial stiffening rather than a direct measure of arterial stiffness
Cite This Study
Mehta et al. (2013) studied this question.
Topics
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