The frequency of cardiac arrhythmias in wake and sleep was studied in 18 patients admitted to a coronary care unit. No significant differences were found in the distribution of ventricular premature contractions (VPCs) or atrial premature contractions (APCs) in either wake or sleep. A tendency for ventricular premature contractions to occur more commonly during wake-sleep transitions than during sleep transition periods (NREM-REM) was noted but this did not attain significance.
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Richard Smith (1972) studied this question.
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