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January 18, 2014Experimental Physiology

Age and sex differences in muscle sympathetic nerve activity in relation to haemodynamics, blood volume and left ventricular size

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Population

70 healthy, normotensive adults, comprising 20 young men, 20 young women, 15 older men, and 15 older women.

Design

Cross-sectional

Authors

SBStuart BestYOYoshiyuki OkadaMGM Galbreath

Discussion

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Overview

Hypothesis-generating for sex-specific sympathetic BP control; leaves open causality and relevance to women or clinical practice.

Structured PICO

P
Population
70 healthy, normotensive adults, comprising 20 young men (19-47 years), 20 young women (21-46 years), 15 older men (62-80 years), and 15 older women (60-82 years).
O
Outcome
Resting muscle sympathetic nerve activity (MSNA) and its relationship with hemodynamics, blood volume, and left ventricular size and masssurrogate

Age-related increases in muscle sympathetic nerve activity are associated with decreased blood volume and increased forearm vascular resistance in men but not women, highlighting sex-specific neural control of blood pressure.

Cite This Study

Best et al. (2014) studied this question.

synapsesocial.com/papers/6a6fd17ec1a24a6142db6616https://doi.org/10.1113/expphysiol.2013.077248
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