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August 12, 2020Hypertension

Influence of Sex and Age on Muscle Sympathetic Nerve Activity of Healthy Normotensive Adults

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Population

658 normotensive healthy nonmedicated volunteers, including 398 males and 260 females

Design

Cross-sectional

Key result

Female sex was associated with lower resting MSNA burst frequency compared to males until age 50 (17 vs 25 bursts/min; P<1x10^-19), after which values converged.

Authors

DKDaniel A. KeirMBMark B. BadrovGTGeorge Tomlinson

Discussion

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Overview

Sex- and age-specific MSNA patterns should not alter practice in normotensives; leaves open longitudinal studies on hypertension risk.

Study Design

Type

Cross-Sectional (n=658)

Structured PICO

P
Population
658 healthy, normotensive, nonmedicated adult volunteers aged 18 to 81 years evaluated for age- and sex-related changes in muscle sympathetic nerve activity.
O
Outcome
Resting muscle sympathetic nerve activity (MSNA) burst frequencysurrogate

In healthy normotensive adults, muscle sympathetic nerve activity increases nonlinearly after age 30, with a significantly steeper age-related increase observed in women compared to men.

Cite This Study

Keir et al. (2020) conducted a cross-sectional in Healthy normotensive adults (n=658). Female sex vs. Male sex was evaluated on Resting MSNA burst frequency. Female sex was associated with lower resting MSNA burst frequency compared to males until age 50 (17 vs 25 bursts/min; P<1x10^-19), after which values converged.

synapsesocial.com/papers/6a215b636edeeecbd302fec1https://doi.org/10.1161/hypertensionaha.120.15208
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