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July 21, 2010Journal of Biomedical ScienceOpen Access

hnRNP A1 interacts with the genomic and subgenomic RNA promoters of Sindbis virus and is required for the synthesis of G and SG RNA

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Population

Sindbis virus (SV)-infected cells and an in vitro system

Design

Preclinical

Authors

HGHongxing GuiCLChi-Wei LuSASandra D. Adams

Discussion

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Overview

May inform host-targeted alphavirus strategies; leaves open translation from cell-based findings to clinical use.

Structured PICO

P
Population
Sindbis virus (SV)-infected cells and an in vitro system
I
Intervention
Knockdown of hnRNP A1
O
Outcome
Synthesis of genomic (G) and subgenomic (SG) RNAsurrogate

hnRNP A1 actively participates in viral RNA replication and is required for the synthesis of Sindbis virus genomic and subgenomic RNA.

Cite This Study

Gui et al. (2010) studied this question.

synapsesocial.com/papers/6a6fd2e4febe604dd708a9cbhttps://doi.org/10.1186/1423-0127-17-59
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1hnRNP A1 Interacts with the 5′ Untranslated Regions of Enterovirus 71 and Sindbis Virus RNA and Is Required for Viral Replication2009 · 179 citations
  2. 2Binding of hnRNP I–vRNA Regulates Sindbis Virus Structural Protein Expression to Promote Particle Infectivity2022 · 6 citations
  3. 3Commandeering of the cellular HuR protein by alphaviruses affects the regulation of host post-transcriptional gene expression2007
  4. 4The multifarious roles of heterogeneous ribonucleoprotein A1 in viral infections2020 · 21 citations
  5. 5The hnRNP A2B1 is important for the replication of SFTSV and other RNA viruses2024 · 5 citations