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January 1, 2023Translational Journal of the American College of Sports Medicine

Both groups improved over time in power (P=0.001), cross-sectional area of vastus lateralis and biceps femoris (P=0.001), and VO2max (P=0.003), with the BFR group achieving a higher output in maximum power.

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Why the study?

The study was designed to investigate the effects of isovolumetric training with versus without blood flow restriction on muscle hypertrophy, power, strength, and aerobic capacity.

Does low-intensity blood flow restriction training improve muscle size, power, and VO2max compared to high-intensity training without restriction in active adults?

Population

20 participants

Comparison

Isovolumetric training with blood flow restriction vs training without blood flow restriction

Design

Randomized controlled trial

Follow-up

4 wk

Authors

KBKathryn M. BradleyJBJennifer A. BunnYFYuri Feito

Discussion

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Overview

BFR and higher-intensity training produced similar gains with lower RPE in BFR; leaves open efficacy in clinical populations.

Structured PICO

Does low-intensity blood flow restriction training improve muscle size, power, and VO2max compared to high-intensity training without restriction in active adults?

P
Population
20 active adults (mean age 30.2 years)
I
Intervention
Blood flow restriction (BFR) training applied to thighs bilaterally at 80% occlusion, rowing at 40% maximum power output and lifting 30% 1-RM for 1 × 20 reps and 3 × 10 reps, twice weekly for 4 weeks
C
Comparator
Control training without BFR, rowing at 80% power and lifting 60% 1-RM for 1 × 10 reps and 3 × 5 reps, twice weekly for 4 weeks
O
Outcome
Muscle hypertrophy (bilateral thigh circumference, cross-sectional area of vastus lateralis and biceps femoris), power output, strength (estimated 1-RM deadlift), and aerobic capacity (VO2max) at 4 weekssurrogate

Cite This Study

Bradley et al. (2023) studied this question.

synapsesocial.com/papers/6a6fd7cc26a7f98052dc6cf0https://doi.org/10.1249/tjx.0000000000000219
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of a low-load multi-component training program with blood flow restriction versus the same program without blood flow restriction on muscle thickness and functional outcomes in physically inactive young adults: randomized controlled trial2026 · 1 citations
  2. 2Effects of Blood Flow Restriction Non-Linear Periodization Strength Training on Muscle Strength and Function in Elite Athletes2022
  3. 3Does Peripheral Lower Body Blood Flow Restriction Training Effect Aerobic Adaptations in Recreationally Active Adults? A Case Series2022
  4. 4Physiological mechanisms underlying enhanced performance with blood flow restriction training: neuromuscular, vascular and metabolic adaptations2025 · 7 citations
  5. 5Effects of Different Blood Flow Restriction Training Modes on Body Composition and Maximal Strength of Untrained Individuals2024 · 3 citations