Key result
Cardiopulmonary bypass increased fibrinolytic activity throughout extracorporeal circulation, which returned to normal postoperatively with no bleeding observed.
Why the study?
Does cardiopulmonary bypass influence fibrinolytic activity in patients undergoing coronary artery bypass operations?
Observational (n=8)
Does cardiopulmonary bypass influence fibrinolytic activity in patients undergoing coronary artery bypass operations?
Answers are grounded in this paper and cite their sources.
Cardiopulmonary bypass transiently increases fibrinolytic activity, which normalizes postoperatively without causing bleeding in this small cohort.
The influence of cardiopulmonary bypass on fibrinolytic activity was assessed by a sensitive clot lysis assay in eight patients undergoing coronary artery bypass operations. Fibrinolytic activity increased immediately after cardiopulmonary bypass was begun and remained elevated throughout the period of extracorporeal circulation. At the conclusion of the operative procedure, fibrinolytic activity returned to the normal range in all patients, and no subject had postoperative bleeding.
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Küçük et al. (1986) conducted an observational in Coronary artery bypass operations (n=8). Cardiopulmonary bypass was evaluated on Fibrinolytic activity. Cardiopulmonary bypass increased fibrinolytic activity throughout extracorporeal circulation, which returned to normal postoperatively with no bleeding observed.
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