What question did this study set out to answer?

To evaluate the prevalence, temporal patterns, and clinical characteristics associated with respiratory syncytial virus subgroups A and B across six consecutive yearly outbreaks.

August 1, 1989The Journal of Infectious Diseases

Prevalence of Respiratory Syncytial Virus Subgroups Over Six Consecutive Outbreaks: 1981-1987

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Authors

RHR. M. HendryUniversitas Al-washliyah Labuhanbatu LPL T PierikBoston Children's Hospital KMKenneth McIntoshUniversity of Strathclyde

Discussion

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Implication

Surveillance study demonstrates shifting dominance between respiratory syncytial virus subgroups A and B across seasonal outbreaks in infants, indicating localized viral transmission patterns.

Key Points

To evaluate the prevalence, temporal patterns, and clinical characteristics associated with respiratory syncytial virus subgroups A and B across six consecutive yearly outbreaks.
Analyzed 981 respiratory syncytial virus isolates collected from hospitalized infants across six successive outbreaks between 1981 and 1987.
Identified viral phenotypes using indirect immunofluorescence with strain-specific monoclonal antibodies and evaluated intra-subgroup variation with an expanded antibody panel.
Subgroup A accounted for 60% (591/981) and subgroup B accounted for 39% (383/981) of total isolates, with subgroup A dominating three outbreaks (93% of isolates), subgroup B dominating one outbreak (89% of isolates), and both co-circulating in equal proportions in two outbreaks.
No significant differences were identified between subgroup A and subgroup B infections regarding patient age, gender distribution, or the frequency of nosocomial acquisition.
Expanded monoclonal antibody profiling revealed substantial antigenic heterogeneity among circulating subgroup A isolates.

Cite This Study

Hendry et al. (1989) studied this question.

synapsesocial.com/papers/6a6fdc07a528af2d65c33263 https://doi.org/10.1093/infdis/160.2.185

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Implication

Surveillance study demonstrates shifting dominance between respiratory syncytial virus subgroups A and B across seasonal outbreaks in infants, indicating localized viral transmission patterns.

Prevalence of Respiratory Syncytial Virus Subgroups Over Six Consecutive Outbreaks: 1981-1987

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevalence of Respiratory Syncytial Virus Subgroups Over Six Consecutive Outbreaks: 1981-1987

Discussion

Member takes

Implication

Key Points

Cite This Study

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