Why the study?
Does delayed ischemic preconditioning reduce infarct size in a conscious rabbit model of myocardial ischemia-reperfusion?
Population
Conscious rabbits chronically instrumented with a coronary artery occluder and ECG electrodes, n=14.
Comparison
Ischemic preconditioning with 4 cycles of 5-min… vs Control animals undergoing 30-min coronary…
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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Does not support clinical adoption; leaves open translation of delayed preconditioning from conscious rabbits to humans.
Does delayed ischemic preconditioning reduce infarct size in a conscious rabbit model of myocardial ischemia-reperfusion?
A delayed phase of ischemic preconditioning (second window of protection) exists in conscious rabbits, reducing infarct size and arrhythmias, and is associated with increased cytoprotective proteins.
Yang et al. (1996) studied this question.
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