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June 4, 2018Acta Physiologica

Muscle mass and inspired oxygen influence oxygen extraction at maximal exercise: Role of mitochondrial oxygen affinity

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Population

7 individuals

Comparison

Incremental exercise tests to exhaustion on a… vs Normoxia vs Hyperoxia, and Bicycle vs Knee…

Design

Other

Authors

DCDaniele A. CardinaleFLFilip J. LarsenMJMats Jensen‐Urstad

Discussion

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Overview

p50 mito may shape O2 extraction with muscle mass and hyperoxia; leaves open relevance to clinical exercise testing.

Structured PICO

P
Population
7 individuals
I
Intervention
Incremental exercise tests to exhaustion on a bicycle ergometer (BIKE) and 1-legged knee extension ergometer (KE) in normoxia (NORM) or hyperoxia (HYPER)
C
Comparator
Normoxia vs Hyperoxia, and Bicycle vs Knee Extension
O
Outcome
O2 extraction and O2 uptake during exercisesurrogate

Mitochondrial excess capacity maintains a low p50 mito, enhancing O2 diffusion from microvessels to mitochondria during exercise.

Cite This Study

Cardinale et al. (2018) studied this question.

synapsesocial.com/papers/6a6fdd7fb27f158178271bbfhttps://doi.org/10.1111/apha.13110
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determinants of maximal exercise VO2 during single leg knee-extensor exercise in humans1995 · 177 citations
  2. 2Hyperoxia does not increase peak muscle oxygen uptake in small muscle group exercise1999 · 59 citations
  3. 3Effects of FIO2 on leg ??VO2 during cycle ergometry in sedentary subjects1998 · 66 citations
  4. 4Lung function, arterial saturation and oxygen uptake in elite cross country skiers: influence of exercise mode2006 · 82 citations
  5. 5Dynamic knee extension as model for study of isolated exercising muscle in humans1985 · 387 citations