Key result
In trained subjects, breathing 100% O2 increased skeletal muscle VO2 max to 1.28 ml/min/ml and intracellular PO2 to 4.1 Torr, suggesting an approach to maximal mitochondrial capacity.
Why the study?
Does varying inspired oxygen concentration (hypoxia vs hyperoxia) affect skeletal muscle VO2 max and intracellular PO2 during maximal exercise in trained humans?
Does varying inspired oxygen concentration (hypoxia vs hyperoxia) affect skeletal muscle VO2 max and intracellular PO2 during maximal exercise in trained humans?
Absolute Event Rate: 1.28% vs 1.08%
In trained skeletal muscle, VO2 max is supply-limited even in hyperoxia, and very high mitochondrial metabolic limits are approached under 100% O2.
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Hyperoxia may further raise muscle VO2max in trained athletes; leaves open whether mitochondrial capacity ultimately limits performance.
Richardson et al. (1999) studied Healthy trained subjects (n=5). Hypoxia (12% O2) and Hyperoxia (100% O2) vs. Normoxia (21% O2) was evaluated on Skeletal muscle VO2 max. In trained subjects, breathing 100% O2 increased skeletal muscle VO2 max to 1.28 ml/min/ml and intracellular PO2 to 4.1 Torr, suggesting an approach to maximal mitochondrial capacity.
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