Key result
Varying inspired O2 fraction significantly altered VO2 max during isolated knee extensor exercise (1.04, 1.24, and 1.45 l/min at 0.12, 0.21, and 1.0 FIO2, respectively; P<0.05).
Why the study?
Does varying inspired O2 fraction affect maximal O2 delivery and VO2 max in trained subjects during knee extensor exercise?
Population
7 trained subjects
Comparison
Maximum knee extensor exercise in hypoxia and… vs Maximum knee extensor exercise in normoxia
Design
Other, balanced order
Authors
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O2 supply limits VO2 max even in isolated exercise; leaves open extension to whole-body or clinical settings.
Does varying inspired O2 fraction affect maximal O2 delivery and VO2 max in trained subjects during knee extensor exercise?
p-value: p=<0.05
Even in isolated quadriceps exercise where normoxic O2 delivery is extremely high, VO2 max is limited by O2 supply rather than mitochondrial metabolic rate.
Richardson et al. (1999) studied Healthy trained subjects (n=7). Variations in inspired O2 fraction (hypoxia and hyperoxia) vs. Normoxia (0.21 FIO2) was evaluated on Maximal O2 uptake (VO2 max) (p=<0.05). Varying inspired O2 fraction significantly altered VO2 max during isolated knee extensor exercise (1.04, 1.24, and 1.45 l/min at 0.12, 0.21, and 1.0 FIO2, respectively; P<0.05).
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