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April 1, 1995AJP Heart and Circulatory Physiology

Determinants of maximal exercise VO2 during single leg knee-extensor exercise in humans

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Why the study?

Does breathing 12% O2 reduce VO2max during single leg incremental knee-extensor exercise in trained men?

Population

5 trained men

Comparison

Breathing 12% O2 during single leg incremental… vs Breathing air during single leg incremental…

Design

Other

Authors

RRRussell S. RichardsonVascular MedicineDKD. R. KnightThe Ohio State UniversityDPDavid C. PooleHeart Failure & Transplant

Discussion

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Implication

May constrain hypoxic exercise testing in trained athletes; leaves open diffusion limitation as VO2max determinant in whole-body settings.

Structured PICO

Does breathing 12% O2 reduce VO2max during single leg incremental knee-extensor exercise in trained men?

P
Population
5 trained men
I
Intervention
Breathing 12% O2 (hypoxia) during single leg incremental knee-extensor exercise to VO2max
C
Comparator
Breathing air (normoxia) during single leg incremental knee-extensor exercise to VO2max
O
Outcome
VO2max (maximum O2 uptake)surrogate

Hypoxia reduces quadriceps muscle VO2max during single leg knee-extensor exercise, supporting the theory of diffusion limitation to VO2max.

Cite This Study

Richardson et al. (1995) studied this question.

synapsesocial.com/papers/6a211efa1311b8b9709690adhttps://doi.org/10.1152/ajpheart.1995.268.4.h1453
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia?1986 · 243 citations
  2. 2Dynamic knee extension as model for study of isolated exercising muscle in humans1985 · 387 citations
  3. 3Gas exchange and peripheral diffusion limitation1992 · 128 citations
  4. 4Blood flow in exercising muscles by xenon clearance and by microsphere trapping1984 · 64 citations
  5. 5Muscular Exercise, Lactic Acid, and the Supply and Utilization of Oxygen1923 · 1,004 citations