Population
Dog gracilis muscles
Design
Preclinical
Authors
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Supports cytochrome aa3 kinetics equivalence in vivo and in vitro; leaves open translation to human muscle physiology.
The mechanism of action of cytochrome aa3 is the same in red muscle in vivo as in mitochondria in vitro, with an upper bound on the apparent Michaelis constant for maximal VO2 of approximately 0.06 Torr.
Gayeski et al. (1987) studied this question.
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