Key result
Intracellular PO2 remains remarkably uniform across species despite large variations in left ventricular work.
Why the study?
The intracellular PO2 in individual cardiac myocytes across multiple species and its relation to myocardial oxygen dynamics was not well characterized.
Population
1,000 individual subepicardial myocytes from 20 animals (dogs, cats, rabbits, ferrets, rats)
Comparison
None, observational measurement of Mb saturation and PO2
Design
Preclinical study using cryospectroscopy
Authors
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Conserved myocyte PO2 across species suggests fundamental oxygen homeostasis; leaves open translation to human HF or ischemia.
Intracellular PO2 in cardiac myocytes is remarkably uniform across multiple mammalian species despite large variations in cardiac work and heart rate.
Gayeski et al. (1991) studied this question. Intracellular PO2 measurement was evaluated on Intracellular PO2 in equilibrium with myoglobin (PMbO2). Median intracellular PO2 in equilibrium with myoglobin was remarkably uniform among species (range, 4.3-7.0 Torr), despite large variations in left ventricular work, heart rate, and arterial O2.
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