Key result
In an in vivo dog model, myocyte oxygenation was maintained over a wide range of inspired oxygen fractions, and oxygen availability only limited mitochondrial oxidative phosphorylation when intracellular PO2 fell below 7.4 mmHg.
Population
25 adult mongrel dogs of either sex weighing 20–27 kg.
Comparison
Graded hypoxia via sequential reductions of the… vs Baseline conditions and complete left anterior…
Design
Preclinical
Authors
Loading...
Hypothesis-generating for myocyte hypoxia thresholds; should not yet alter clinical oxygen targets.
In an in vivo dog model, adequate myocyte oxygenation and mitochondrial oxidative phosphorylation are maintained until extremely low arterial pO2 levels (FIO2 < 5%) are reached.
Jameel et al. (2014) studied Hypoxia (n=25). Graded hypoxia (reduction of FIO2) vs. Baseline (FIO2 40%) was evaluated on Intracellular PO2 and high energy phosphate levels. In an in vivo dog model, myocyte oxygenation was maintained over a wide range of inspired oxygen fractions, and oxygen availability only limited mitochondrial oxidative phosphorylation when intracellular PO2 fell below 7.4 mmHg.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: