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December 15, 1996Journal of Clinical InvestigationOpen Access

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation.

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Authors

ZLZ. LingVrije Universiteit BrusselDPDaniël PipeleersVrije Universiteit Brussel

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Cite This Study

Ling et al. (1996) studied this question.

synapsesocial.com/papers/6a6fde2ae5469ee92be0adffhttps://doi.org/10.1172/jci119108
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Chronically Elevated Glucose Levels on the Functional Properties of Rat Pancreatic β-Cells1996 · 104 citations
  2. 2Abnormal Glucose Regulation of Insulin Secretion in Models of Reduced B-Cell Mass1984 · 84 citations
  3. 3Effects of High Glucose on Insulin Secretion by Isolated Rat Islets and Purified β-Cells and Possible Role of Glycosylation1989 · 68 citations
  4. 4Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: evidence supporting specific desensitization rather than beta-cell exhaustion1992 · 35 citations
  5. 5Heterogeneity in Pancreatic β-cell Population1992 · 220 citations