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February 1, 1997Journal of Clinical InvestigationOpen Access

Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15.

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Authors

AMA. MoranUniversity of Minnesota Children's HospitalHZH J ZhangInstitute for Nuclear ResearchLOL. Karl OlsonMichigan State University

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Moran et al. (1997) studied this question.

synapsesocial.com/papers/6a748ad4b35e02fb1503280ahttps://doi.org/10.1172/jci119190
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.1996 · 159 citations
  2. 2Differentiating Glucose Toxicity From Glucose Desensitization: A New Message From the Insulin Gene1994 · 174 citations
  3. 3Severe Diabetes Induced in Subtotally Depancreatized Dogs by Sustained Hyperglycemia1988 · 111 citations
  4. 4Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells.1981 · 378 citations
  5. 5Glucose Toxicity1990 · 777 citations