What question did this study set out to answer?

This research investigates the firing characteristics of single vasoconstrictor neurones in individuals with high muscle sympathetic activity.

April 1, 1999The Journal of PhysiologyOpen Access

Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activity

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Population

21 healthy subjects

Comparison

Sustained inspiratory-capacity apnoea vs Resting state, and comparison between 'high' and…

Design

Other

Authors

VMVaughan G. MacefieldElectrophysiology BWB. G. WallinUniversity of Gothenburg

Discussion

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Implication

Apnoea augments single-unit vasoconstrictor firing; hypothesis-generating for sympathetic mechanisms in sleep-disordered breathing.

Key Points

This research investigates the firing characteristics of single vasoconstrictor neurones in individuals with high muscle sympathetic activity.
Single-unit recordings from 19 postganglionic muscle vasoconstrictor axons in the peroneal nerve of seven healthy subjects.
Subjects divided into high and low sympathetic activity groups based on multi-unit bursts observed at rest.
Firing probability and frequency were measured during rest and apnoea to assess changes in sympathetic activity.
In the high group, units fired in 35% of cardiac intervals, with a mean rate of 0.33 Hz at rest.
During apnoea, firing frequency increased to 1.04 Hz, with 56% firing probability observed in the high group.
Differences in sympathetic bursts at rest were attributed to variations in firing probability and the recruitment of sympathetic fibres.

Structured PICO

Population

21 healthy subjects (7 in 'high group' with many multi-unit sympathetic discharges at rest, 14 in 'low group' with fewer bursts)

Intervention

Sustained inspiratory-capacity apnoea (in the high group)

Comparator

Resting state, and comparison between 'high' and 'low' sympathetic discharge groups

Outcome

Firing properties of single vasoconstrictor neurones (firing probability, spikes per cardiac interval, mean rate, intraburst frequency)surrogate

Differences in sympathetic burst numbers between individuals are mainly due to differences in firing probability and recruitment of sympathetic fibres, rather than multiple spikes per burst.

Cite This Study

Macefield et al. (1999) studied this question.

synapsesocial.com/papers/6a6fde5cc1a24a6142db6779 https://doi.org/10.1111/j.1469-7793.1999.293aa.x

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Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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