Safety of Alpha-Adrenergic Receptor Antagonists in Heart Failure

Cynthia A. Jackevicius; Zunera Ghaznavi; Lingyun Lu; Alberta L. Warner

doi:10.1016/j.jchf.2018.06.015

October 10, 2018JACC Heart FailureOpen Access

Safety of Alpha-Adrenergic Receptor Antagonists in Heart Failure

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Why the study?

Does alpha-blocker use reduce heart failure readmission or death in patients discharged with heart failure?

Structured PICO

Does alpha-blocker use reduce heart failure readmission or death in patients discharged with heart failure?

P

Population

169,911 patients discharged from a Veterans Affairs hospital between January 2002 and September 2015 with a primary diagnosis of heart failure (propensity score-matched cohort of 35,713 pairs).

I

Intervention

Alpha-blocker (AB) prescription at discharge.

C

Comparator

No alpha-blocker prescription at discharge (propensity score-matched).

O

Outcome

Time to first heart failure readmission and death at 2 years.hard clinical

Implication

Contrary to previous concerns from the ALLHAT trial, alpha-blocker use in heart failure patients is associated with a lower risk of mortality and heart failure readmission.

Abstract

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Discussion

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Cite This Study

Jackevicius et al. (2018) studied this question.

synapsesocial.com/papers/6a6fdf80af0c21e93927d36c https://doi.org/10.1016/j.jchf.2018.06.015

View Full Paper

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Safety of Alpha-Adrenergic Receptor Antagonists in Heart Failure

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Safety of Alpha-Adrenergic Receptor Antagonists in Heart Failure

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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