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November 23, 2023Journal of Experimental & Clinical Cancer ResearchOpen Access

Transcriptomic landscape based on annotated clinical features reveals PLPP2 involvement in lipid raft-mediated proliferation signature of early-stage lung adenocarcinoma

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Why the study?

Image-based screening for early-stage lung adenocarcinoma has high false-positive rates leading to unnecessary over-treatment, necessitating more precise discrimination criteria.

Population

158 early-stage LUAD cases from 2 independent cohorts

Design

Integrative multi-cohort transcriptomic and translational study

Authors

YWYibei WangZMZiwei MiaoXQXiaoxue Qin

Discussion

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Overview

PLPP2 may aid prognostication in early lung adenocarcinoma; leaves open whether lipid raft targeting improves outcomes.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Wang et al. (2023) studied this question.

synapsesocial.com/papers/6a6fdfc2e5469ee92be0af3chttps://doi.org/10.1186/s13046-023-02877-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease2004 · 214 citations
  2. 2Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains2013 · 3,932 citations
  3. 3Lipid Rafts As a Membrane-Organizing Principle2009 · 4,498 citations
  4. 4MYC Oncogene Contributions to Release of Cell Cycle Brakes2019 · 263 citations
  5. 5Lipid Phosphate Phosphatases and Cancer2020 · 50 citations