Why the study?
Does a weight-based heparin nomogram reduce the time to achieve therapeutic anticoagulation in patients with acute deep vein thrombosis or pulmonary embolism compared to traditional dosing?
Does a weight-based heparin nomogram reduce the time to achieve therapeutic anticoagulation in patients with acute deep vein thrombosis or pulmonary embolism compared to traditional dosing?
A weight-based heparin nomogram significantly reduces the time to achieve therapeutic anticoagulation compared to traditional nonweight-based dosing without increasing adverse outcomes.
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May accelerate time to therapeutic aPTT in acute VTE; leaves open need for randomized outcome trials before practice change.
Shalansky et al. (1996) studied this question.
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